Prickle isoforms determine handedness of helical morphogenesis

Prickle isoforms determine handedness of helical morphogenesis

Blog Article

Subcellular asymmetry directed by the planar cell polarity (PCP) signaling pathway orients numerous morphogenetic events in both invertebrates and vertebrates.Here, we describe a morphogenetic movement in which jazzy select gt parts the intertwined socket and shaft cells of the Drosophila anterior wing margin mechanosensory bristles undergo PCP-directed apical rotation, inducing twisting that results in a helical structure of defined chirality.We show that the Frizzled/Vang PCP signaling module coordinates polarity among and between bristles and surrounding cells to direct this rotation.Furthermore, we show that dynamic interplay between two isoforms of the Prickle protein determines right- or left-handed bristle morphogenesis.

We provide bosch 4100 table saw motor replacement evidence that, Frizzled/Vang signaling couples to the Fat/Dachsous PCP directional signal in opposite directions depending on whether Pkpk or Pksple predominates.Dynamic interplay between Pk isoforms is likely to be an important determinant of PCP outcomes in diverse contexts.Similar mechanisms may orient other lateralizing morphogenetic processes.